Faculty of Exact and Natural Sciences

Z7_NQ5E12C0LOF160QDKRNCOGGJA1

Research group

Spanish

Genetics, Regeneration and Cancer

Academic Unit: Faculty of Exact and Natural Sciences

Colombian Ministry of Science

A

Call

894 GrupLAC

OECD

Area

Natural sciences

Subarea

Biological sciences

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Strategic Focus

To identify the molecular and cellular mechanisms that are involved in cancer and regeneration processes in order to contribute to the transfer of knowledge and technology to develop regenerative medicine therapies for humans.

Research Lines and/or Areas

Occupational genotoxicology in populations exposed to industrial carcinogens in Cerro Matoso S.A. and Ecopetrol.
Microbial genetics.
Population genetics.
Toxicological genetics and environmental mutacarcinogenesis.
Tumor genetics.
Regenerative medicine.
Genetically modified microorganisms.
Analysis on the X chromosome inactivation and its relation to breast cancer.
Regenerative biology.
Cell cycle.
Cytogenetics and anti-cytostatic agents in leukemoid cells.
DNA damage, repair and oxidative stress.
Molecular diagnosis in humans.
Molecular epidemiology of Streptococcus pneumoniae.
Susceptibility genes in gastrointestinal cancer.

Sustainable Development Goals (SDGs)

Group Coordinator

Belfran Carbonell Medina

Coordinator's Email

laboratorio.grc@udea.edu.co

Scientific Cooperation

Collaborative Relationships

Universidad EAFIT, Colombia.
Universidad CES, Colombia.
The University of Kentucky, USA.

Jackson Laboratories, USA.
Karolinska Institute.
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.

Highlighted Projects

Identifying molecules with anti-cancer and regenerative potential from Colombian biodiversity amphibians.
Creation of transgenic salamanders to elucidate regenerative mechanisms such as the loss of a limb.
Molecular biomonitoring of the genotoxic damage caused by pollution from the Aburra Valley.
Description of the regenerative process in Colombian salamanders.
Creation of molecular databases from technological amphibians.

Key Research Findings

Identifying peptides with antimicrobial and anti-cancer potential from Colombian frogs and salamanders.
Description of regenerative processes on a morphological and cellular level in Colombian salamanders.
Creation of molecular databases from Colombian salamanders.
Creation of the first transgenic vertebrate in Colombia.

Services and/or Products Portfolio

Cell cycle analysis
Analysis of proliferation, cytotoxicity, and apoptosis.
Analysis on the effect of drugs and natural or semi-synthetic compounds.
Isolation of tissue cell lines or tumors.
Cytogenetics description and cell lines karyotypes.
Occupational cytogenetic biomonitoring (mining, refinery, etc.).
Analysis of the toxicity and genetic effect of drugs and natural or semi-synthetic compounds.
Citogenotoxicity test for bioactive substances and cosmetics.
Analysis on oxidative stress in blood cells and cell lines.
Cytogenetic test on micronucleus.
In vivo micronucleus test through flow cytometry.
Chromatid exchange test for alkylating agents or cross-linking agents.